One thing I think the comics folks are going to be disappointed with is how free of them the casual market really is, for the most part.
My comparison here being the difference in completeness. A casual comic collector who wants every Wolverine comic for instance needs to get every one of them, and the whole lot of em are the same - just a comic. But in video games you see people all the time sharing their "complete" sets of Franchise X on social media, and they have the cart games cart-only. There are tiers of options available, and I honestly can't see them buying up all the Mario 3 carts to try to game that specific bit of the market.
CIB was already pretty niche comparatively, and sealed far moreso; specific rare variants most people don't even register as a thing that exists. So they can buy up all the CIB Mario 3 all they want, but it will really only impact those specifically into CIB collecting, and let's face it - the vast majority of us who collect CIB already have Mario 3, and probably in pretty decent condition due to the not-scarce nature of it.
I think there's going to be some interesting growing pains for the comic guys coming into this, and some potential surprises for them.